I just unplug it. It's plug and play. The assigned serial port will not change if you do not change the usb port. If you do plug it into another usb port and the operating system of your choice assigned another serial port to it, you can easily modify the new serial port assign to it in the hardware screen. No need to disable, enable stuff. Domoticz will ignore it when not present, and will use it when it is.
They only hardware that has to be "safely" ejected are* harddrives, flashdrives or any other memory drive like sd cards. And the only reason for that is that there could be data in cache memory of those drives that is not written to the disk and manufactures are too "cheap" to add a battery or capacitor such that the cache can be written to disk after power failure. Luckily, after more then 20 years since the introduction of the usb implementation (which promised us full plug and play!) and with the introduction of ssd
https://en.wikipedia.org/wiki/Solid-sta ... _capacitor (as a boot disk) they started doing that. Only on expensive ssd and on some very expensive usb drives flash drives though (but then again I could be wrong, can't keep up these days

). The other reason is unplugging it in the middle of a file write operation (like file copying) will corrupt your data...
* yeah yeah, probably there is other hardware that writes and have crappy implementation on how to deal with it.