Moving to Intel Nuc from Raspberry

[waltervl]

I do not believe buster on a Nuc is supported by domoticz.
Domoticz on x86 will need bullsey (like min Ubuntu
20.04 LTS).

[kiddigital]

Don’t think you can run an ARM based VM on an X86 host.

But running Domoticz on X86 Linux is no problem (either Ubuntu or Debian should work).

But why not run it in a Docker container instead?

One thing to consider, using a VM or Container could be a little difficult with your USB connected devices (Z-wave stick, etc) as mapping and data passthrough from and to your your host.

[waltervl]

Docker not needed if you are not familiar with Docker. I run normal Domoticz on a x86 Ubuntu 20.04 LTS system without issues.
Domoticz Docker needs some special extra installation steps so my personal opinion is to just use the x86 pre built version (called Linux).
Install Linux (Debian, Ubuntu), run the install script
curl -sSL install.domoticz.com | sudo bash
and you are ready.
Database and scripts can be copied from your raspberry system.