Hello,

on OSX, the tty USB port are not /dev/ttyUSBx

For the AEON stick it is :
/dev/tty.SLAB_USBtoUART and /dev/cu.SLAB_USBtoUART

In order to use it with domoticz, you have to create a symbolic link with /dev/cu.SLAB_USBtoUART.

sudo ln -s /dev/cu.SLAB_USBtoUART /dev/ttyUSB0

unfortunately ...